Bead Ruptor Elite

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The Bead Ruptor Elite is a high-performance bead mill homogenizer engineered for high-throughput, automated homogenization of tough tissue, plant, and microbial samples.

Ideal for labs requiring reproducible results, the Elite homogenizer streamlines workflows and delivers consistent performance across a wide range of biological and clinical applications.

Its unique sealed, inclined carriage system enables rapid, uniform sample disruption with minimal heat generation—preserving the integrity of sensitive biomolecules such as RNA, DNA, and proteins.

Processing range: 25 µL to 50 mL
Run Time: 1 second to 9:59 minutes
Performance range: 0.8 – 8 m/s in increments of 0.15 m/s
Number of Cycles: 1-10
Safety: integrated lid lock to prevent lid opening during operation
Waterproof seal
Dimensions: W: 15” (38.1 cm), D: 17” (43.2 cm), H: 13” (33.0 cm)
No cool down
Unlimited protocols
Touchscreen with user defined programs, tube configuration and parameter control
Power rating: 115-230 VAC, 50/60 Hz
Product weight: 65 lbs. (29 kg)
Warranty: one year
Standards approval: TUV, CE and UKCA approved

Top Bead Ruptor Elite Use Cases & App Notes

NGS & Genomic Sequencing

High-throughput NGS starts with consistent nucleic acid extraction. The Elite’s mechanical lysis avoids heat and enzymatic degradation, delivering high-purity DNA and RNA—essential for reproducible read depth and clean variant calling.

RNA Expression Analysis

In-depth analysis of RNA expression begins with sample lysis. Since RNA is a fragile biomolecule, attention must be paid when selecting a lysis protocol that doesn’t destroy the RNA before it gets analyzed. Elite brings just the right amount of power and reliability to lyse tissue samples without harming delicate RNA analytes.

LC-MS & Metabolite Analysis

In small-molecule workflows, variability at the sample prep stage can throw off quantitation. Elite enables uniform disruption across biological matrices like tissue, plasma, and umbilical cord—so your downstream data reflects biology, not prep inconsistencies.

Biomarker Discovery

When detecting subtle shifts in protein or RNA expression, even small prep inconsistencies can create false signals. Elite minimizes variability and protects fragile molecules, giving you higher-confidence hits from your panels.

Microbiome & 16S Sequencing

Some bacteria are tough to lyse—especially in stool, soil, or environmental samples. Elite’s high-G-force bead milling ensures complete disruption, unlocking accurate microbial profiling and reducing bias toward easier-to-lyse species.

HEAD-TO-HEAD COMPARISON

Manual Sample Prep vs Bead Ruptor Elite

Typical Time Savings in Preparing 24 Samples

The comparison was created using soft and hard tissue types commonly used in biological research, including mouse liver, skeletal muscle, kidney, lung, heart, and spleen, as well as MCF7 cultured cells. Homogenization times for the Bead Ruptor Elite were calculated using data from five recent application notes published by Omni R&D. All application notes used 2 mL tubes and followed standard tissue lysis protocols.

Manual preparation, in the context of this comparison, is based on protocols using a mortar and pestle to lyse tissue—an approach that introduces significant variability and requires hands-on time for each sample. All pipetting steps were considered using a single-channel pipette.

Sample Processing Step	Time it Takes to Manually Prep (in min)	Time It Takes Using LH 96 (in min)
Sample Weighing	720	650
Buffer Addition, Homogenization, Sample Reformatting	576	335
Average Time Spent Cleaning Stainless Steel (SS) Probes Used in Manual Method¹	1920²	–
Total Time Preparing and Cleaning	3216	985

Manual preparation, in the context of this comparison, is defined as using a handheld motorized tissue homogenizer to individually homogenize 1 sample at a time for a 45-second cycle. All pipetting/reformatting steps were considered using a single-channel pipette.

Note: stainless steel probes are typically used when manually creating tissue lysates using a motorized tissue homogenizer. Time spent cleaning these probes in-between samples can range depending on cleaning method from as little as 5 minutes to wipe down and clean probe vs. 1 hour to autoclave the probe.

Features	BR Elite	Competitor 1	Competitor 2	Competitor 3
Unique inclined carriage motion designed to maximize lysis efficiency
Engineered for highest sample yield and quality
Broadest G-Force for precision tuning of homogenization
Accommodates different samples and size within single device
User-Centric inclined carriage for ease of use
No cool down time between sample runs
Integrated transparent locking lid for improved safety and access
Industrial, no-maintenance build for lowest total cost of ownership
Broadest tube size compatibility for unparalleled flexibility in sample size
Near silent operation (<72dB) minimizing noise

Labs That Trust Elite

BAKO

Washing University

Regeneron

Pfizer

NIH

Mount Sinai

Abbvie

5.0 RATING

“Powerful homogenization in a small footprint. A must-have for every laboratory.”

Application Area: Trace residue analysis in crop and environmental samples.

"Our Bead Ruptor has been an enormous time saver. Previously sample homogenization of multiple samples could be a bottleneck. Especially if multiple chemists needed to use our traditional homogenizers, which are expensive and take up a lot of bench space. The Bead Ruptor makes quick work of multiple samples at once."

– Steven Perez
ADPEN Laboratories, Inc.

5.0 RATING

“Drastically increased efficiency and decreased turnaround times”

Application Area: Analyzing pig veins and arteries for various compounds.

“For years, I was analyzing pig veins and arteries for various compounds. I was manually homogenizing them in a variety of diluents using a handheld homogenizer with a stainless steel tip. This was a very labor-intensive process that required the use of glass vials. With the OMNI Bead Ruptor, I was able to transfer the sample tissue to a bead ruptor tube with ceramic beads and homogenize multiple samples simultaneously. This drastically increased efficiency in the laboratory and decreased turnaround times for our clients.”

– Chad Dean

Senior Research Scientist, Laboratory
Services, Bioanalytical Lab

PPD Early Preclinical Research

Thermo Fisher Scientific

5.0 RATING

“It is easier to use, safer (no solvent splashes), and quieter (no hearing protection required)”

Application Area: Homogenize animal tissues in organic solvents.

"We purchased this product to replace a traditional shearing homogenizer. It is easier to use, safer (no solvent splashes), and quieter (no hearing protection required). It is programmable, ensuring consistent handling of all samples. It processes up to 24 samples simultaneously. It is very powerful. We process most of our samples for two to three cycles at 10 to 15 seconds per cycle."

– Bonne Thompson
UT Southwestern Med Ctr

ABOUT OMNI

Commitment to Support

At Omni, we don’t just sell products and disappear.

We pride ourselves on providing unrivaled customer support—our relationship with you goes far beyond the purchase. Our team of dedicated scientists and engineers works closely with you to ensure that your LH 96 is fully customized for your unique workflows.

From setup to troubleshooting, we offer personalized assistance every step of the way, ensuring seamless integration and maximum performance.
Unlike others in the industry, Omni’s support is proactive and ongoing, with experts readily available to provide real-time solutions and tailored guidance. When you choose Omni, you’re not just buying a product—you’re gaining a partner who’s as invested in your lab’s success as you are.

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